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PACMA 31
CAS No. 1401089-31-3
PACMA 31 ( —— )
Catalog No. M28353 CAS No. 1401089-31-3
PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 53 | Get Quote |
|
| 5MG | 87 | Get Quote |
|
| 10MG | 147 | Get Quote |
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| 25MG | 327 | Get Quote |
|
| 50MG | 533 | Get Quote |
|
| 100MG | 767 | Get Quote |
|
| 500MG | 1557 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePACMA 31
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NoteResearch use only, not for human use.
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Brief DescriptionPACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.
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DescriptionPACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.(In Vitro):In OVCAR-8 cells, PACMA 31 (0-10 μM) potently inhibits colony formation in a dose-dependent manner.(In Vivo):In human ovarian cancer mouse xenografts, PACMA 31 (20-200 mg/kg) i.p. or per os administration of significantly inhibited tumor growth by 85% and 65% at day 62, respectively.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorP-gp
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Research Area——
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Indication——
Chemical Information
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CAS Number1401089-31-3
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Formula Weight430.5
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Molecular FormulaC21H22N2O6S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C#C)N(C1=CC=C(OC)C=C1OC)C(C(=O)NCC(=O)OCC)C=2SC=CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yuan S, et al. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors. J Med Chem. 2021;64(19):14895-14911.
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