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PACMA 31

CAS No. 1401089-31-3

PACMA 31 ( —— )

Catalog No. M28353 CAS No. 1401089-31-3

PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 53 Get Quote
5MG 87 Get Quote
10MG 147 Get Quote
25MG 327 Get Quote
50MG 533 Get Quote
100MG 767 Get Quote
500MG 1557 Get Quote
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Biological Information

  • Product Name
    PACMA 31
  • Note
    Research use only, not for human use.
  • Brief Description
    PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.
  • Description
    PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.(In Vitro):In OVCAR-8 cells, PACMA 31 (0-10 μM) potently inhibits colony formation in a dose-dependent manner.(In Vivo):In human ovarian cancer mouse xenografts, PACMA 31 (20-200 mg/kg) i.p. or per os administration of significantly inhibited tumor growth by 85% and 65% at day 62, respectively.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    P-gp
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1401089-31-3
  • Formula Weight
    430.5
  • Molecular Formula
    C21H22N2O6S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C#C)N(C1=CC=C(OC)C=C1OC)C(C(=O)NCC(=O)OCC)C=2SC=CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yuan S, et al. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors. J Med Chem. 2021;64(19):14895-14911.
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